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Name :
LAD1 antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
LAD1 Rabbit Polyclonal antibody. Positive WB detected in HepG2 cells, HeLa cells, mouse skin tissue. Positive IHC detected in human kidney tissue, human brain tissue, human testis tissue. Observed molecular weight by Western-blot: 48kd

Tested applications :
ELISA, WB, IHC

Species reactivity :
Human, Mouse; other species not tested.

Alternative names :
LAD antibody; Lad 1 antibody; LAD1 antibody; LadA antibody; ladinin 1 antibody; Linear IgA disease antigen antibody

Immunogen :

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of LAD1 recombinant protein (Accession Number: NM_005558). Purification method: Antigen affinity purified.

Clonality :
Polyclonal

Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:500-1:5000IHC: 1:20-1:200

Background :
Ladinin-1, also named as LADA, or LAD1, is an anchoring filament protein which is a component of the basement membrane zone. It is a novel component of the basement membranes and may function in contributing to the stability of the association of the epithelial layers with the underlying mesenchyme. Human ladinin is an autoantigen associated with linear IgA disease. It is a secreted protein. Immunohistochemical staining of 16136-1-AP shows strong extracellular matrixc positivity in human testis. The predicted MW of this protein is 57 kDa. Both IP and WB result of 16136-1-AP detected 48 kDa band which may due to post-translation cleavage.

References :

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
Related websites: https://www.medchemexpress.com/antibodies.html
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Author: Gardos- Channel