Name :
Lamin B1 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
Lamin B1 Mouse Monoclonal antibody. Positive IP detected in HeLa cells. Positive WB detected in HeLa cells. Positive FC detected in HeLa cells. Positive IF detected in HepG2 cells. Observed molecular weight by Western-blot: 66 kDa
Tested applications :
ELISA, WB, IF, FC, IP
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
ADLD antibody; lamin B1 antibody; LMN antibody; LMN2 antibody; LMNB antibody; LMNB1 antibody
Immunogen :
Isotype :
Mouse IgG1
Preparation :
This antibody was obtained by immunization of Lamin B1 recombinant protein (Accession Number: NM_005573). Purification method: Protein G purified.
Clonality :
Monoclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:5000-1:50000IP: 1:5000-1:50000IF: 1:20-1:200
Background :
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. This protein is not suitable for samples where the nuclear envelope has been removed.
References :
Tan T, Lu B, Zhang J. Notch1 signaling antagonizes transforming growth factor-β pathway and induces apoptosis in rabbit trophoblast stem cells. Stem cells and development. 23(8):813-22. 2014. Chen L, Zhang W, Liang HF. Activin A induces growth arrest through a SMAD- dependent pathway in hepatic progenitor cells. Cell communication and signaling : CCS. 12:18. 2014. Song E, Yu W, Xiong X, Kuang X, Ai Y, Xiong X. Astrocyte elevated gene-1 promotes progression of cervical squamous cell carcinoma by inducing epithelial-mesenchymal transition via Wnt signaling. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. 25(3):345-55. 2015. Liu H, Wang ZC, Bai YG. Simulated microgravity promotes monocyte adhesion to rat aortic endothelium via nuclear factor-κB activation. Clinical and experimental pharmacology & physiology. 42(5):510-9. 2015. Bai L, Zhang W, Tan L. Hepatitis B virus hijacks CTHRC1 to evade host immunity and maintain replication. Journal of molecular cell biology. 7(6):543-56. 2015. Chen H, Sun Y, Lai L. Interleukin-33 is released in spinal cord and suppresses experimental autoimmune encephalomyelitis in mice. Neuroscience. 308:157-68. 2015. Zhang J, Li T, Ji W, Yu Y, Tan T. Rho GDIalpha Modulates Rabbit Trophoblast Stem Cell Survival and Migration. Biology of reproduction. 93(6):144. 2015. Nie D, Zhang D, Dai J. Nicotine Induced Murine Spermatozoa Apoptosis via Up-Regulation of Deubiquitinated RIP1 by Trim27 Promoter Hypomethylation. Biology of reproduction. 94(2):31. 2016.
Related websites: https://www.medchemexpress.com/antibodies.html
Popular product recommendations:
Sirukumab Autophagy
Mogamulizumab MedChemExpress
Glu-Glu Tag Antibody: Glu-Glu Tag Antibody is a non-conjugated and Mouse origined monoclonal antibody, targeting to Glu-Glu Tag. It can be used for WB assays with Glu-Glu-tag, in the background of Species independent.
