Name :
LARP7 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
LARP7 Rabbit Polyclonal antibody. Positive WB detected in HeLa cells, human brain tissue, mouse liver tissue. Positive IHC detected in human kidney. Observed molecular weight by Western-blot: 67kd
Tested applications :
ELISA, WB, IHC
Species reactivity :
human, mouse, rat; other species not tested.
Alternative names :
LARP7 antibody; PIP7S antibody; DKFZp564K112 antibody; HDCMA18P antibody; La related protein 7 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of LARP7 recombinant protein (Accession Number: BC006981). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000IHC: 1:20-1:200
Background :
LARP7 belongs to the LARP RNA-binding protein family, which includes the lupus LA antigen gene, and modulates the metabolism and function of a variety of RNA species [PMID:20138158]. LARP7 binds to the 7SK RNP complex, and sequesters the positive transcription elongation factor b (P-TEFb) in an inactive form, preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. binds to and stabilizes 7sk snRNA[PMID:19416841].
References :
Eilebrecht S, Brysbaert G, Wegert T, Urlaub H, Benecke BJ, Benecke A. 7SK small nuclear RNA directly affects HMGA1 function in transcription regulation. Nucleic acids research. 39(6):2057-72. 2011. Alazami AM, Al-Owain M, Alzahrani F. Loss of function mutation in LARP7, chaperone of 7SK ncRNA, causes a syndrome of facial dysmorphism, intellectual disability, and primordial dwarfism. Human mutation. 33(10):1429-34. 2012. Eilebrecht S, Benecke BJ, Benecke A. 7SK snRNA-mediated, gene-specific cooperativity of HMGA1 and P-TEFb. RNA biology. 8(6):1084-93. 2012. Eilebrecht S, Le Douce V, Riclet R. HMGA1 recruits CTIP2-repressed P-TEFb to the HIV-1 and cellular target promoters. Nucleic acids research. 42(8):4962-71. 2014. Okamura D, Maeda I, Taniguchi H. Cell cycle gene-specific control of transcription has a critical role in proliferation of primordial germ cells. Genes & development. 26(22):2477-82. 2012.
Related websites: https://www.medchemexpress.com/antibodies.html
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