Name :
LIAS antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
LIAS Rabbit Polyclonal antibody. Positive IHC detected in human lymphoma tissue. Positive WB detected in human brain tissue. Observed molecular weight by Western-blot: 42kd
Tested applications :
ELISA, WB, IHC
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
HUSSY 01 antibody; LAS antibody; LIAS antibody; Lip syn antibody; LIP1 antibody; Lipoate synthase antibody; Lipoic acid synthase antibody; lipoic acid synthetase antibody; Lipoyl synthase antibody; mitOChondrial antibody
Immunogen :
Human LIAS Recombinant protein (GST tag)
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of LIAS recombinant protein (Accession Number: NM_006859). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000IHC: 1:20-1:200
Background :
LIAS(lipoyl synthase, mitochondrial) is also named as LAS and belongs to the radical SAM superfamily and lipoyl synthase family. It produces alpha-lipoic acid, an antioxidant and an essential cofactor in alpha-ketoacid dehydrogenase complexes, which participate in glucose oxidation and ATP generation(PMID:22021711). The deduced 373-amino acid protein has a calculated molecular mass of about 42 kD. The N-terminal 26 amino acids encode a potential mitochondrial targeting presequence that, upon removal, would result in a deduced mature protein of 347 amino acids with a molecular mass of about 39 kD(PMID:11389890). Defects in LIAS are a cause of pyruvate dehydrogenase lipoic acid synthetase deficiency (PDHLD).
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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