Name :
LKB1 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
LKB1 Rabbit Polyclonal antibody. Positive IP detected in HEK-293 cells. Positive WB detected in HEK-293 cells, Jurkat cells. Positive IHC detected in human lymphoma tissue, human liver tissue, human lung cancer tissue, human skin tissue, human testis tissue. Observed molecular weight by Western-blot: 54 kDa
Tested applications :
ELISA, WB, IHC, IP
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
LKB1 antibody; PJS antibody; serine/threonine kinase 11 antibody; STK11 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of LKB1 recombinant protein (Accession Number: NM_000455). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:2000IP: 1:200-1:2000IHC: 1:20-1:200
Background :
STK11(serine/threonine-protein kinase 11) is also named as LKB1,PJS,and belongs to the protein kinase superfamily. It controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response.The tumour suppressor protein LKB1 is a serine/threonine kinase that has been causally linked to Peutz-Jeghers syndrome (PJS).Defects in STK11 are a cause of Peutz-Jeghers syndrome (PJS) and defects in STK11 have been associated with testicular germ cell tumor (TGCT) and some sporadic cancers, especially lung cancers.
References :
Zhao F, Huang W, Zhang Z. Triptolide induces protective autophagy through activation of the CaMKKβ-AMPK signaling pathway in prostate cancer cells. Oncotarget. 2015. Nakada Y, Stewart TG, Peña CG. The LKB1 tumor suppressor as a biomarker in mouse and human tissues. PloS one. 8(9):e73449. 2013. Yang JY, Jiang SH, Liu DJ. Decreased LKB1 predicts poor prognosis in Pancreatic Ductal Adenocarcinoma. Scientific reports. 5:10575. 2015.
Related websites: https://www.medchemexpress.com/antibodies.html
Popular product recommendations:
Anti-Mouse IFN gamma Antibody (H22) Biological Activity
Phospho-Smad1 (Ser463/Ser465) Rabbit mAb medchemexpress
FXR1 Antibody: FXR1 Antibody is an unconjugated, approximately 70 kDa, rabbit-derived, anti-FXR1 monoclonal antibody. FXR1 Antibody can be used for: WB, IHC-P, ICC/IF, FC expriments in human, mouse, rat background without labeling.
