Name :
LMP7 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
LMP7 Rabbit Polyclonal antibody. Positive IF detected in HepG2 cells. Positive IHC detected in human lymphoma tissue. Positive FC detected in HepG2 cells. Positive WB detected in mouse kidney tissue, human kidney tissue, Jurkat cells, Raji cells. Positive IP detected in Raji cells. Observed molecular weight by Western-blot: 22 kDa
Tested applications :
ELISA, WB, IHC, IF, FC, IP
Species reactivity :
Human, Mouse; other species not tested.
Alternative names :
beta5i antibody; D6S216 antibody; D6S216E antibody; LMP7 antibody; Low molecular mass protein 7 antibody; Macropain subunit C13 antibody; Proteasome component C13 antibody; Proteasome subunit beta 5i antibody; Proteasome subunit beta type 8 antibody; PSMB5i antibody; PSMB8 antibody; RING10 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of LMP7 recombinant protein (Accession Number: NM_004159). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000IP: 1:500-1:5000IHC: 1:20-1:200IF: 1:20-1:200
Background :
PSMB8(Proteasome subunit beta type-8) is also named as LMP7, PSMB5i, RING10, Y2 and belongs to the peptidase T1B family. The gene encodes the chymotrypsin-like catalytic subunit of the immunoproteasome(PMID: 19525961). PSMB8 has a role in controlling pathogenic immune responses and may be a target in autoimmune disorders. Its prosequence is not essential for incorporation of PSMB8 into the maturing proteasome, but it increased the efficiency of PSMB8 incorporation and proteasome maturation(PMID: 10926487). Defects in PSMB8 are the cause of Nakajo syndrome (NKJO).
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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