Name :
LOX antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
LOX Rabbit Polyclonal antibody. Positive IHC detected in human placenta tissue, human heart tissue, human skin tissue, human stomach cancer tissue. Positive IP detected in mouse skeletal muscle tissue. Positive WB detected in Jurkat cells, A375 cells, MKN-45 cells, mouse skeletal muscle tissue, NIH/3T3 cells, SGC-7901 cells. Observed molecular weight by Western-blot: 32kd or 45-47kd
Tested applications :
ELISA, WB, IHC, IP
Species reactivity :
Human, Mouse; other species not tested.
Alternative names :
LOX antibody; lysyl oxidase antibody; Protein lysine 6 oxidase antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of LOX recombinant protein (Accession Number: NM_002317). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:2000IP: 1:200-1:2000IHC: 1:20-1:200
Background :
LOX is a member of a multigene family (LOX, LOXL, LOXL2, LOXL3, and LOXL4). Lysyl oxidase (LOX), a copper-dependent enzyme, plays a critical role in the formation and repair of the extracellularmatrix (ECM) by catalyzing the crosslinking of elastin and collagen. LOX expression appears to be upregulated in malignancies and has recently been suggested to play a role in regulating tumor metastasis. It is synthesized as a 50 kDa proenzyme, secreted, and processed into an 32 kDa mature, active enzyme and an 18-kDa propeptide.
References :
Shu G, Mi X, Cai J. Brucine, an alkaloid from seeds of Strychnos nux-vomica Linn., represses hepatocellular carcinoma cell migration and metastasis: the role of hypoxia inducible factor 1 pathway. Toxicology letters. 222(2):91-101. 2013. Cowling RT, Yeo SJ, Kim IJ. Discoidin domain receptor 2 germline gene deletion leads to altered heart structure and function in the mouse. American journal of physiology. Heart and circulatory physiology. 307(5):H773-81. 2014. Jiang J, Sun A, Wang Y, Deng Y. Increased expression of Talin1 in the eutopic and ectopic endometria of women with adenomyosis. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 2016.
Related websites: https://www.medchemexpress.com/antibodies.html
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