Name :
LRPPRC antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
LRPPRC Rabbit Polyclonal antibody. Positive IHC detected in human heart tissue, human kidney tissue. Positive IF detected in HepG2 cells, HEK-293 cells, Hela cells. Positive IP detected in HeLa cells. Positive WB detected in HepG2 cells, HeLa cells, mouse heart tissue, mouse kidney tissue, mouse liver tissue, mouse skeletal muscle tissue, rat kidney tissue, rat liver tissue. Observed molecular weight by Western-blot: 130 kDa
Tested applications :
ELISA, WB, IHC, IF, IP
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
130 kDa leucine rich protein antibody; CLONE 23970 antibody; GP130 antibody; LRP 130 antibody; LRP130 antibody; LRPPRC antibody; LSFC antibody
Immunogen :
Human LRPPRC Recombinant protein (GST tag)
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of LRPPRC recombinant protein (Accession Number: NM_133259). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:1000-1:10000IP: 1:500-1:5000IHC: 1:20-1:200IF: 1:10-1:100
Background :
LRPPRC (also called LRP130 or GP130) is a 130-kDa RNA-binding protein of the pentatricopeptide repeat family. LRPPRC localizes primarily to the mitochondria where it binds to poly(A) mRNA. It plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. LRPPRC has also been shown to regulate nuclear gene transcription and to bind specific RNA molecules in both the nucleus and the cytoplasm. Mutations in LRPPRC gene are associated with the French-Canadian type of Leigh syndrome.
References :
Chen L, Lai Y, Zhu X. The role of specific PP2A complexes in the dephosphorylation of γH2AX. Journal of cell science. 128(2):421. 2015. Ma Y, Yao N, Liu G. Functional screen reveals essential roles of miR-27a/24 in differentiation of embryonic stem cells. The EMBO journal. 34(3):361-78. 2015.
Related websites: https://www.medchemexpress.com/antibodies.html
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