Name :
MCCC2 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
MCCC2 Rabbit Polyclonal antibody. Positive IHC detected in human pancreas cancer. Positive WB detected in human liver tissue. Observed molecular weight by Western-blot: 61kd
Tested applications :
ELISA, WB, IHC
Species reactivity :
human, mouse, rat; other species not tested.
Alternative names :
MCCC2 antibody; MCCase subunit beta antibody; MCCB antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of MCCC2 recombinant protein (Accession Number: BC014897). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:2000IHC: 1:20-1:200
Background :
MCCC2(Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial) is also named as MCCB and belongs to the AccD/PCCB family. The putative 563-amino acid polypeptide has a calculated molecular mass of 61 kD and contains an N-terminal mitochondrial targeting sequence(PMID:11181649). It catalyzes carboxylation of 3 methylcrotonyl COA to form 3 methylglutaconyl-COA and is probably a dodecamer composed of six biotin-containing alpha subunits and six beta subunits. Defects in MCCC2 are the cause of methylcrotonoyl-CoA carboxylase 2 deficiency (MCC2D).
References :
Pang J, Liu WP, Liu XP. Profiling protein markers associated with lymph node metastasis in prostate cancer by DIGE-based proteomics analysis. Journal of proteome research. 9(1):216-26. 2010. Dai J, Zhan C, Xu W. Nicotine elevates sperm motility and induces Pfn1 promoter hypomethylation in mouse testis. Andrology. 3(5):967-78. 2015.
Related websites: https://www.medchemexpress.com/antibodies.html
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