Name :
MCL1L-specific antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
MCL1L-specific Rabbit Polyclonal antibody. Positive IHC detected in human spleen tissue, human brain tissue, human breast cancer tissue, human cervical cancer tissue, human kidney tissue, human lung tissue, human ovary tissue, human placenta tissue, human skin tissue, human testis tissue, human tonsillitis tissue.
Tested applications :
ELISA, IHC
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
EAT antibody; Mcl 1 antibody; Mcl 1l antibody; Mcl 1s Delta TM antibody; MCL1 antibody; mcl1/EAT antibody; MCL1L antibody; MCL1S antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of Peptide (Accession Number: NM_182763). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: IHC: 1:20-1:200
Background :
MCL-1 is an anti-apoptotic member of the Bcl-2 family originally isolated from the ML-1 human myeloid leukemia cell line. Similar to BCL2 and BCL2L1, MCL1 can interact with BAX and/or BAK1 to inhibit mitochondria-mediated apoptosis. Mcl-1 is critical for the proliferation and survival of myeloma cells in vitro, and overexpression of Mcl-1 protein in myeloma cells is associated with relapse and short event-free survival in multiple myeloma patients. Recent studies show that MCL-1 is upregulated in numerous haematological and solid tumour malignancies. Therefore, MCL-1 has been suggested as a potential new therapeutic target. This antibody is specific to MCL1L isoform.
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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