Name :
MCM4 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
MCM4 Rabbit Polyclonal antibody. Positive WB detected in HeLa cells, HEK-293 cells, HL-60 cells, human liver tissue. Positive IP detected in HEK-293 cells. Observed molecular weight by Western-blot: 97 kDa
Tested applications :
ELISA, WB, IP
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
CDC21 antibody; CDC21 homolog antibody; CDC54 antibody; hCdc21 antibody; MCM4 antibody; P1 CDC21 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of MCM4 recombinant protein (Accession Number: NM_005914). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000IP: 1:200-1:2000
Background :
DNA replication licensing factor MCM4 (MCM4), also named Cdc21, acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for ‘once per cell cycle’ DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.This antibody is a rabbit polyclonal antibody raised against the C-terminal 350 aa sequence of MCM4 protein.
References :
Valle BL, D’Souza T, Becker KG. Non-steroidal anti-inflammatory drugs decrease E2F1 expression and inhibit cell growth in ovarian cancer cells. PloS one. 8(4):e61836. 2013.
Related websites: https://www.medchemexpress.com/antibodies.html
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