Name :
Anti-Calumenin antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
Rabbit polyclonal to Calumenin
Tested applications :
ELISA, WB, IP
Species reactivity :
Human Calumenin / CALU
Alternative names :
9530075H20Rik antibody; Calu antibody; CALU antibody; Calumenin antibody; Calumenin antibody; crocalbin antibody; crocalbin antibody; crocalbin-like protein antibody; IEF SSP 9302 antibody; multiple EF-hand protein antibody; 9530075H20Rik antibody
Immunogen :
Human Calumenin (His Tag) recombinant protein
Isotype :
Rabbit IgG
Preparation :
Produced in rabbits immunized with purified, recombinant Human Calumenin / CALU (rh Calumenin / CALU; O43852-1; Met1-Arg311). Calumenin / CALU specific IgG was purified by Human Calumenin / CALU affinity chromatography.
Clonality :
Polyclonal
Formulation :
0.2 μm filtered solution in PBS
Storage instructions :
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Applications :
WB: 2-10 μg/mlELISA: 0.1-0.2 μg/mlThis antibody can be used at 0.1-0.2 μg/ml with the appropriate secondary reagents to detect Human Calumenin / CALU. The detection limit for Human Calumenin / CALU is IP: 4-6 uL/mg of lysate
Background :
Calumenin belongs to the CREC family. It contains 6 EF-hand domains. Calumenin is expressed in skeletal muscle (at protein level). Calumenin interacts with GGCX and RYR1 in the presence of calcium ions, but not in the presence of EDTA. Calumenin is Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. It seems to inhibit gamma-carboxylase GGCX. Calumenin also binds 7 calcium ions with a low affinity and may modulate calcium release from the sarcoplasmic reticulum.
References :
Hartley JL, et al. (2001) DNA cloning using in vitro site-specific recombination. Genome Res. 10 (11):1788-95. Vorum H, et al. (2000) Calumenin interacts with serum amyloid P component. FEBS Lett. 465 (2-3):129-34. Vorum H, et al. (1999) n calumenin localizes to the secretory pathway and is secreted to the medium. Exp Cell Res. 248(2):473-81.
Related websites: https://www.medchemexpress.com/antibodies.html
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