Name :
MGP antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
MGP Mouse Monoclonal antibody. Positive IHC detected in human lung tissue, human brain tissue, human gliomas tissue. Positive WB detected in Transfected HEK-293 cells, human brain tissue, human kidney tissue. Observed molecular weight by Western-blot: 12 kDa
Tested applications :
ELISA, IHC, WB
Species reactivity :
Human, Mouse; other species not tested.
Alternative names :
GIG36 antibody; matrix Gla protein antibody; MGLAP antibody; MGP antibody; NTI antibody
Immunogen :
Isotype :
Mouse IgG2a
Preparation :
This antibody was obtained by immunization of MGP recombinant protein (Accession Number: NM_000900). Purification method: Caprylic acid/ammonium sulfate precipitation.
Clonality :
Monoclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000IHC: 1:20-1:200
Background :
Matrix Gla protein (MGP) is is a vitamin K-dependent, extracellular matrix protein. MGP plays a pivotal role in preventing soft tissue calcification and local mineralization of the vascular wall. Vitamin K deficiency leads to inactive uncarboxylated MGP (ucMGP), which accumulates at sites of arterial calcification. However MGP is synthesized in many tissues and is especially enriched in embryonic tissues and in cancer cells. Defects in MGP are the cause of Keutel syndrome (KS), which is an autosomal recessive disorder characterized by abnormal cartilage calcification, peripheral pulmonary stenosis neural hearing loss and midfacial hypoplasia.
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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