Name :
MIG6; ERRFI1 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
MIG6; ERRFI1 Rabbit Polyclonal antibody. Positive IHC detected in human breast cancer tissue, human tonsillitis tissue. Positive IF detected in PC-3 cells. Positive WB detected in HeLa cells, human brain tissue, mouse brain tissue, rat colon tissue, Recombinant protein. Observed molecular weight by Western-blot: 51 kDa
Tested applications :
ELISA, IHC, WB, IF
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
ERRFI1 antibody; GENE 33 antibody; MIG 6 antibody; MIG6 antibody; RALT antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of MIG6; ERRFI1 recombinant protein (Accession Number: NM_018948). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000IHC: 1:20-1:200IF: 1:20-1:200
Background :
The mitogen inducible gene 6 (MIG6) is located in human chromosome 1p36, a locus frequently associated with human lung cancer. MIG6 gene expression can be rapidly induced by factors including hormones, growth factor, and stresses. MIG6 encodes ERBB receptor feedback inhibitor 1 (ERRFI1) levels of which are very low in quiescent cells but upregulated by mitogens. MIG6 may play important roles in regulating stress response, maintaining homeostasis in tissues like joints or cardiac muscle, and functioning as a tumor suppressor.
References :
Li Z, Dong Q, Wang Y, Qu L, Qiu X, Wang E. Downregulation of Mig-6 in nonsmall-cell lung cancer is associated with EGFR signaling. Molecular carcinogenesis. 51(7):522-34. 2012. Staal B, Williams BO, Beier F, Vande Woude GF, Zhang YW. Cartilage-specific deletion of Mig-6 results in osteoarthritis-like disorder with excessive articular chondrocyte proliferation. Proceedings of the National Academy of Sciences of the United States of America. 111(7):2590-5. 2014. Ajiro M, Jia R, Yang Y, Zhu J, Zheng ZM. A genome landscape of SRSF3-regulated splicing events and gene expression in human osteosarcoma U2OS cells. Nucleic acids research. 44(4):1854-70. 2016.
Related websites: https://www.medchemexpress.com/antibodies.html
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