Name :
MLLT3 Polyclonal Antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
Polyclonal antibody to MLLT3
Tested applications :
WB
Species reactivity :
Human, Mouse, Rat
Alternative names :
MLLT3 antibody; AF9 antibody; YEATS3 antibody; protein AF-9 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human MLLT3 (NP_004520.2).
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage instructions :
Store at -20℃. Avoid freeze / thaw cycles.
Applications :
WB 1:500 – 1:2000
Background :
Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Specifically recognizes and binds acylated histone H3, with a marked preference for histone H3 that is crotonylated. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. Recognizes and binds histone H3 crotonylated at ‘Lys-9’ (H3K9cr), and with slightly lower affinity histone H3 crotonylated at ‘Lys-18’ (H3K18cr). Also recognizes and binds histone H3 acetylated at ‘Lys-9’ (H3K9ac), but with lower affinity than crotonylated histone H3. In the SEC complex, MLLT3 is required to recruit the complex to crotonylated histones.
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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