Name :
MLN51/CASC3 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
MLN51/CASC3 Rabbit Polyclonal antibody. Positive IF detected in HepG2 cells. Positive WB detected in A2780 cells, Jurkat cells, MCF7 cells, SKOV-3 cells. Observed molecular weight by Western-blot: 115-120 kDa
Tested applications :
ELISA, WB, IF
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
BTZ antibody; CASC3 antibody; MLN 51 antibody; MLN51 antibody; Protein barentsz antibody; Protein CASC3 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of MLN51/CASC3 recombinant protein (Accession Number: XM_005257163). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000IF: 1:10-1:100
Background :
CASC3(cancer susceptibility candidate 3) is also named as MLN51 and belongs to the CASC3 family. It is induced by CSF2, and is important in the proliferation of RA fibroblast-like synoviocytes in the pathogenesis of rheumatoid arthritis (RA)(PMID:17101062). It is a nucleocytoplasmic protein containing, within its aminoterminal half, a coiled-coil domain followed by two nuclear localization signals (NLSs) responsible for nuclear localization and, in its carboxyl-terminal half, a nuclear export signal(NES) that mediates cytoplasmic retention. It possesses many potential phosphorylation sites and is found to be phosphorylated in both normal and cancer-derived cells.(PMID:17652158).
References :
Daguenet E, Baguet A, Degot S. Perispeckles are major assembly sites for the exon junction core complex. Molecular biology of the cell. 23(9):1765-82. 2012. Bruno IG, Karam R, Huang L. Identification of a microRNA that activates gene expression by repressing nonsense-mediated RNA decay. Molecular cell. 42(4):500-10. 2011.
Related websites: https://www.medchemexpress.com/antibodies.html
Popular product recommendations:
PPAR gamma Rabbit mAb site
HOPX Antibody Epigenetics
CRK Antibody (YA790): CRK Antibody (YA790) is a non-conjugated and Mouse origined monoclonal antibody about 34 kDa, targeting to CRK (3H7). It can be used for WB assays with tag free, in the background of Human.
