Name :
MMP3 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
MMP3 Rabbit Polyclonal antibody. Positive WB detected in A549 cells, A2780 cells, HeLa cells, human skeletal muscle tissue. Positive IHC detected in human breast cancer tissue, human stomach cancer tissue. Positive IF detected in A549 cells. Observed molecular weight by Western-blot: 45-47 kDa
Tested applications :
ELISA, WB, IHC, IF
Species reactivity :
Human, Mouse, Rat; other species not tested.
Alternative names :
CHDS6 antibody; Matrix metalloproteinase 3 antibody; MMP 3 antibody; MMP3 antibody; SL 1 antibody; STMY antibody; STMY1 antibody; STR1 antibody; Stromelysin 1 antibody; Transin 1 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of MMP3 recombinant protein (Accession Number: NM_002422). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000IHC: 1:20-1:200IF: 1:20-1:200
Background :
Matrix metalloproteinases (MMPs) play a critically important role in extracellular matrix remodeling and have been implicated in a number of key normal and pathologic processes.These proteases have come to represent important therapeutic and diagnostic targets for the treatment and detection of human cancers. MMP-3 activate procollagenase via two pathways: slow direct activation and rapid activation in conjunction with tissue or plasma proteinases. The pro-MMP3 (60 kDa) and the active MMP3 (47 kDa) can be detected through western blot.
References :
Fong G, Backman LJ, Hart DA, Danielson P, McCormack B, Scott A. Substance P enhances collagen remodeling and MMP-3 expression by human tenocytes. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 31(1):91-8. 2013. Ding Q, Zhong H, Qi Y. Anti-arthritic effects of crocin in interleukin-1β-treated articular chondrocytes and cartilage in a rabbit osteoarthritic model. Inflammation research : official journal of the European Histamine Research Society … Zhang M, Liu Y, Feng H. CD133 affects the invasive ability of HCT116 cells by regulating TIMP-2. The American journal of pathology. 182(2):565-76. 2013. Yoshioka Y, Kozawa E, Urakawa H. Suppression of hyaluronan synthesis alleviates inflammatory responses in murine arthritis and in human rheumatoid synovial fibroblasts. Arthritis and rheumatism. 65(5):1160-70. 2013. Ding QH, Cheng Y, Chen WP, Zhong HM, Wang XH. Celastrol, an inhibitor of heat shock protein 90β potently suppresses the expression of matrix metalloproteinases, inducible nitric oxide synthase and cyclooxygenase-2 in primary human osteoarthritic chondrocytes. European journal of pharmacology. 708(1-3):1-7. 2013. Zuo X, Pan W, Feng T, Shi X, Dai J. Matrix metalloproteinase 3 promotes cellular anti-dengue virus response via interaction with transcription factor NFκB in cell nucleus. PloS one. 9(1):e84748. 2014. Mehner C, Miller E, Khauv D. Tumor cell-derived MMP3 orchestrates Rac1b and tissue alterations that promote pancreatic adenocarcinoma. Molecular cancer research : MCR. 12(10):1430-9. 2014. Ma F, Li H, Wang H. Enriched CD44(+)/CD24(-) population drives the aggressive phenotypes presented in triple-negative breast cancer (TNBC). Cancer letters. 353(2):153-9. 2014.
Related websites: https://www.medchemexpress.com/antibodies.html
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