Name :
MMP7 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
MMP7 Rabbit Polyclonal antibody. Positive IHC detected in human pancreas cancer tissue, human stomach tissue. Positive WB detected in NIH/3T3 cells, COLO 320 cells, human placenta tissue, mouse lung tissue. Observed molecular weight by Western-blot: 28-30 kDa
Tested applications :
ELISA, WB, IHC
Species reactivity :
Human, Mouse; other species not tested.
Alternative names :
Matrilysin antibody; Matrin antibody; Matrix metalloproteinase 7 antibody; MMP 7 antibody; MMP7 antibody; MPSL1 antibody; PUMP 1 antibody; Pump 1 protease antibody; PUMP1 antibody; Uterine metalloproteinase antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of MMP7 recombinant protein (Accession Number: NM_002423). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:2000IHC: 1:20-1:200
Background :
Matrix metalloproteinase-7 (MMP-7)/ matrilysin is a member of the MMP family, but is structurally different from the other MMPs by virtue of the absence of a conserved COOH-terminal protein domain. MMPs are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and cancer metastasis. Most MMP’s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP-7 degrades proteoglycans, fibronectin, elastin and casein, and is involved in wound healing, tumor progression, pulmonary fibrosis, and development of choroidal neovascularization in age-related macular degeneration. The expression of MMP-7 is increased in most tumors. The gene encoding MMP-7 is part of a cluster of MMP genes which localize to chromosome 11q22.3.
References :
Wang X, Zuo D, Chen Y. Shed Syndecan-1 is involved in chemotherapy resistance via the EGFR pathway in colorectal cancer. British journal of cancer. 111(10):1965-76. 2014. Tan C, Qiao F, Wei P. DIXDC1 activates the Wnt signaling pathway and promotes gastric cancer cell invasion and metastasis. Molecular carcinogenesis. 2015. Huang W, Liu J, Feng X. DLC-1 induces mitochondrial apoptosis and epithelial mesenchymal transition arrest in nasopharyngeal carcinoma by targeting EGFR/Akt/NF-κB pathway. Medical oncology (Northwood, London, England). 32(4):115. 2015. Liu Z, Wei P, Yang Y. BATF2 Deficiency Promotes Progression in Human Colorectal Cancer via Activation of HGF/MET Signaling: A Potential Rationale for Combining MET Inhibitors with IFNs. Clinical cancer research : an official journal of the American Association for Cancer Research. 21(7):1752-63. 2015. Yuan R, Wang K, Hu J. Ubiquitin-like protein FAT10 promotes the invasion and metastasis of hepatocellular carcinoma by modifying β-catenin degradation. Cancer research. 74(18):5287-300. 2014. Liu J, Huang W, Ren C. Flotillin-2 promotes metastasis of nasopharyngeal carcinoma by activating NF-κB and PI3K/Akt3 signaling pathways. Scientific reports. 5:11614. 2015. Yuan G, Qian L, Shi M. HER2-dependent MMP-7 expression is mediated by activated STAT3. Cellular signalling. 20(7):1284-91. 2008. Wei Y, Cui C, Lainscak M. Type-specific dysregulation of matrix metalloproteinases and their tissue inhibitors in end-stage heart failure patients: relationship between MMP-10 and LV remodelling. Journal of cellular and molecular medicine. 15(4):773-82. 2011.
Related websites: https://www.medchemexpress.com/antibodies.html
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