Name :
MMP8 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
MMP8 Rabbit Polyclonal antibody. Positive IHC detected in human placenta tissue, human kidney tissue, human ovary tissue, human spleen tissue, human testis tissue. Positive WB detected in HepG2 cells, Jurkat cells, mouse liver tissue. Positive IP detected in mouse liver tissue. Observed molecular weight by Western-blot: 70 kDa
Tested applications :
ELISA, WB, IHC, IP
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
CLG1 antibody; HNC antibody; Matrix metalloproteinase 8 antibody; MMP 8 antibody; MMP8 antibody; Neutrophil collagenase antibody; PMNL CL antibody; PMNL collagenase antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of MMP8 recombinant protein (Accession Number: NM_002424). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000IP: 1:200-1:2000IHC: 1:20-1:200
Background :
MMP8(Matrix metalloproteinase-8) an enzyme that degrades fibrillar collagens imparting strength to the fetal membranes, is expressed by leukocytes and chorionic cytotrophoblast cells(PMID:15367487). Purified human neutrophil MMP-8 with proeMMP-8 at 75 KDa and active enzyme at 65 KDa and amniochorion proenzyme and active enzyme at 65 and 50 KDa,respectively(PMID:15042023).
References :
Mousa AA, Cappello RE, Estrada-Gutierrez G. Preeclampsia is associated with alterations in DNA methylation of genes involved in collagen metabolism. The American journal of pathology. 181(4):1455-63. 2012. Vagima Y, Zauberman A, Levy Y. Circumventing Y. pestis Virulence by Early Recruitment of Neutrophils to the Lungs during Pneumonic Plague. PLoS pathogens. 11(5):e1004893. 2015.
Related websites: https://www.medchemexpress.com/antibodies.html
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