Product Name :
Ro 0437626
Description:
Ro 0437626 is a selective purinergic (P2X1) receptor antagonist (IC50 = 3 μM), but shows low affinity for P2X2, P2X3 and P2X2/3 receptors (IC50 > 100 μM).
CAS:
134362-79-1
Molecular Weight:
525.66
Formula:
C27H35N5O4S
Chemical Name:
(2R)-2-[(1H-1,3-benzodiazol-2-yl)formamido]-N-[(2S,3R,4R)-1-cyclohexyl-4-cyclopropyl-3,4-dihydroxybutan-2-yl]-3-(1,3-thiazol-4-yl)propanamide
Smiles :
O[C@H](C1CC1)[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@@H](CC1=CSC=N1)NC(=O)C1NC2=CC=CC=C2N=1
InChiKey:
JHRSGCIIDRWHCD-OLKYXYMISA-N
InChi :
InChI=1S/C27H35N5O4S/c33-23(17-10-11-17)24(34)21(12-16-6-2-1-3-7-16)31-26(35)22(13-18-14-37-15-28-18)32-27(36)25-29-19-8-4-5-9-20(19)30-25/h4-5,8-9,14-17,21-24,33-34H,1-3,6-7,10-13H2,(H,29,30)(H,31,35)(H,32,36)/t21-,22+,23+,24+/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Ro 0437626 is a selective purinergic (P2X1) receptor antagonist (IC50 = 3 μM), but shows low affinity for P2X2, P2X3 and P2X2/3 receptors (IC50 > 100 μM).|Product information|CAS Number: 134362-79-1|Molecular Weight: 525.Hyaluronic acid Protocol 66|Formula: C27H35N5O4S|Chemical Name: (2R)-2-[(1H-1,3-benzodiazol-2-yl)formamido]-N-[(2S,3R,4R)-1-cyclohexyl-4-cyclopropyl-3,4-dihydroxybutan-2-yl]-3-(1,3-thiazol-4-yl)propanamide|Smiles: O[C@H](C1CC1)[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@@H](CC1=CSC=N1)NC(=O)C1NC2=CC=CC=C2N=1|InChiKey: JHRSGCIIDRWHCD-OLKYXYMISA-N|InChi: InChI=1S/C27H35N5O4S/c33-23(17-10-11-17)24(34)21(12-16-6-2-1-3-7-16)31-26(35)22(13-18-14-37-15-28-18)32-27(36)25-29-19-8-4-5-9-20(19)30-25/h4-5,8-9,14-17,21-24,33-34H,1-3,6-7,10-13H2,(H,29,30)(H,31,35)(H,32,36)/t21-,22+,23+,24+/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Glipizide Membrane Transporter/Ion Channel |Shelf Life: ≥12 months if stored properly.PMID:32644331 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Ro 0437626 reduces PMA-evoked Ca2+entry with 6.8 ± 4.7% of control.|In Vivo:|Ro 0437626 (1 and 10 μmol/kg; i.v.) causes a reduction in postinfusion isovolumetric contractions.|Products are for research use only. Not for human use.|
